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Price Structure for Gold ConjugatesAurosphere Gold™ contains a constant 62.5 milligrams of gold per liter of suspension, regardless of the size of the particles. Therefore, changing the diameter of the particles changes the number of particles per liter. The concentration of gold in the suspension is approximately correlated with the absorbance (optical density) of the plasmon band in the visible region of the electromagnetic spectrum. For Aurosphere Gold™, the OD of the "bare" particles is about 1.4 to 1.6 at their absorption maximum of 520 to 530 nm. Colloidal gold particles are stabilized and converted into immunoreagents by coating them with various proteins. The amount of product is quantified by measurement of the optical density (OD) of the conjugate at its absorption maximum (lambda max) in the visible region, as with bare particles. After passive or covalent conjugation of the protein to the gold particles, the conjugate can be concentrated and purified by centrifugation or other techniques. The resulting material may be quite concentrated, having an OD in the hundreds. For the purposes of pricing, the volume of the product at its measured OD is extrapolated to that volume which would have an OD of 10. Prices are then quoted per milliliter of conjugate at OD 10. The cost per millileter is scaled according to the total volume of the preparation or lot. For example, a conjugate is prepared with a volume of 5 ml and an OD of 70. If this suspension were diluted to 35ml it would have an OD of 10. The price would be determined for 35ml of product. PLEASE CALL OR E-MAIL TO DISCUSS YOUR NEEDS. Free Samples !Gold conjugates are most commonly prepared from the customer's antibody, normally affinity-purified IgG. Please contact us by e-mail or telephone to arrange for a sample conjugate of your material.
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Marketing: Dr. Robert Siekman Synthetic Colloids, LLC 12 Rice St. Portland, ME 04103 |
